Aging Research

McFarland, C., & Glisky, E. (2011).  Implementation intentions and prospective memory among older adults: An investigation of the role of frontal lobe function.  Aging, Neuropsychology, and Cognition, 18, 633-652.

Walther, K., Bendlin, B., Glisky, E., Trouard, T., Lisse, J., Posever, J., & Ryan, L. (2011).  Anti-inflammatory drugs protect against age-related differences in brain volume. Neurobiology of Aging, 32, 497-505.

Alexander, G. E., Ryan, L., Bowers, D., Foster, T. C., Bizon, J. L., Geldmacher, D. S., & Glisky, E. L.  (2012). Characterizing cognitive aging in humans with links to animal models.  Frontiers in Aging Neuroscience, 4:21. doi: 10.3389/fnagi.2012.00021.

Bizon, J. L., Foster, T. C., Alexander, G. E., & Glisky, E. L. (2012).  Characterizing cognitive aging of working memory and executive function in animal models.  Frontiers in Aging Neuroscience, 4:19. doi: 10.3389/fnagi.2012.00019.

Burke, S.N., Hartzell, A.L. Lister, J.P., Hoang, L.T. & Barnes, C.A. (2012) Layer V perirhinal cortical ensemble activity during object exploration:  A comparison between young and aged rats.  Hippocampus, 22, 2080:2093.

Burke, S.N., Ryan, L. & Barnes, C.A. (2012) Characterizing cognitive aging of recognition memory and related processes in animal models and in humans.  Frontiers in Aging Neuroscience, 4, 15.

Edmonds, E. C., Glisky, E. L., Bartlett, J. C., & Rapcsak, S. Z. (2012).  Cognitive mechanisms of false facial recognition in older adults.  Psychology and Aging, 27, 54-60.

Engle, J.R. & Barnes, C.A. (2012) Characterizing cognitive aging of associative memory in animal models.  Frontiers in Aging Neuroscience, 4, 10.

Hoang, L.T., Lister, J.P. & Barnes, C.A. (2012) The ageing hippocampus.  In: T. Bartsch (Ed) Clinical Neurobiology of the Hippocampus.  Oxford University Press: United Kingdom, pp. 152-173.

Insel, N., Patron, L.A., Hoang, L.T., Nematollahi, S. & Barnes C.A. (2012) Reduced gamma frequency in the medial frontal cortex of aged rats during behavior and rest: Implications for aged-related behavioral slowing.  Journal of Neuroscience, 32, 16331-16344.

Marrone, D.F., Satvat, E., Schaner, M.J., Worley, P.F. & Barnes C.A. (2012) Attenuated long-term Arc expression in the aged fascia dentata.  Neurobiology of Aging, 33, 979-990.

Marrone, D.F., Ramirez-Amaya, V., & Barnes, C.A. (2012) Neurons generated in senescence maintain capacity for functional integration.  Hippocampus, 22, 1134-1142.

Roberson, E. D., DeFazio, R. A., Barnes, C. A., Alexander, G. E., Bizon, J. L., Bowers, D., Foster, T. C., Glisky, E. L., Levin, B. E., Ryan, L., Wright, C. B., & Geldmacher, D. S. (2012).  Challenges and opportunities for characterizing cognitive aging across species.  Frontiers in Aging Neuroscience, 4:6. doi: 10.3389/fnagi.2012.00006.

Rogalski, E.J., Stebbins, G.T., Barnes, C.A., Murphy, C.M., Stoub, T.R., George, S., Ferrari, C., Shah, R.C. & deToledo-Morrell, L. (2012) Age-related changes in parahippocampal white matter integrity: A diffusion tensor imaging study. Neuropsychologia, 50, 1759-1764.

Ryan, L., Cardoza, J.A., Barense, M.D., Kawa, K.H., Wallentin-Flores, J., Arnold, W.T., & Alexander, G.E. (2012) Age-related impairment in a complex object discrimination task engages perirhinal cortex.  Hippocampus, 22, 1978-89.

Stoub, T.R., Barnes, C.A., Shah, R.C., Stebbins, G.T., Ferrari, C. & deToledo-Morrell, L. (2012) Age-related changes in the mesial temporal lobe: The parahippocampal white matter region.  Neurobiology of Aging, 33, 1168-1176.

Chawla, M.K., Penner, M.R., Olson, K.M., Sutherland, V.L., Mittleman-Smith, M.A. & Barnes, C.A. (2013) Spatial behavior and seizure-included changes in c-fos mRNA expression in young and old rats.  Neurobiology of Aging, 34, 1184-1198.

Chou, Y.-H., Chen, N.-K. & Madden, D. J. (2013). Functional brain connectivity and cognition: Effects of adult age and task demands. Neurobiology of Aging, 34(8), 1925-1934. PMCID: PMC3674832.

Hartzell, A.L., Burke, S.N., Hoang, L.T., Lister, J.P., Rodriguez, C.N. & Barnes, C.A. (2013) Transcription of the immediate-early gene Arc in CA1 of the hippocampus reveals activity differences along the proximodistal axis that are attenuated by advanced age.  Journal of Neuroscience, 33, 3424-3433.

Makris, U.E., Melhado, T.V., Lee, S.J.C., Hamann, H.A., Walke, L.M., Gill, T.M., Fraenkel, L. (2014). Illness representations of restricting back pain: The older person’s perspective. Pain Medicine, 15(6), 938-946. PMCID: PMC4116640

Samson, R.D., & Barnes, C.A. (2013) Impact of Aging Brain Circuits on Cognition.  European Journal of Neuroscience, 37, 1903-1915.

Schimanski, L.A., Lipa, P. & Barnes, C.A. (2013) Tracking the course of hippocampal representations during learning: When is the map required?  Journal of Neuroscience, 33, 3094-3106.

Burke, S.N., Thome, A., Plange, K., Engle, J.R., Trouard, T.P., Gothard, K.M., & Barnes, C.A. (2014) Orbitofrontal cortex volume in area 11/13 predicts reward devaluation, but not reversal learning performance, in young and aged monkeys.  Journal of Neuroscience, 34, 905-9916.

Madden, D. J., Parks, E. L., Davis, S. W., Diaz, M. T., Potter, G. G., Chou, Y.-H., Chen, N.-K.,& Cabeza, R. (2014). Age mediation of frontoparietal activation during visual feature search. NeuroImage, 102 (Pt.2), 262-274. PMCID: PMC4253678.

Raichlen, D. & Alexander, G.E. (2014) Exercise, APOE genotype, and the evolution of the human lifespan. Trends in Neurosciences, 37, 247-55.

Samson, R.D., Venkatesh, A., Patel, D.H., Lipa, P. & Barnes, C.A.  (2014) Enhanced performance of aged rats in contingency degradation and instrumental extinction tasks. Behavioral Neuroscience, 128, 122-133.

Burke, S.N. & Barnes, C.A. (2015) The neural representation of 3-dimensional objects in rodent memory circuits.  Behavioral Brain Research, 285, 60-66.

Gray, D.T. & Barnes, C.A. (2015) Distinguishing adaptive plasticity from vulnerability in the aging hippocampus. Neuroscience, 309, 17-28.

Jones, B., Pest, S. M., Vargas, I.M., Glisky, E. L., & Fellous, J-M. (2015). Contextual reminders fail to trigger memory reconsolidation in aged humans and rats.  Neurobiology of Learning and Memory, 7-14.

Li, W. Langkammer, C., Chou, Y.-H., Petrovic, K., Schmidt, R., Song, A. W., Madden, D. J., Ropele, S., & Liu, C. (2015). Association between increased magnetic susceptibility of iron rich gray matter and decreased motor function in healthy adults. NeuroImage, 105, 45-52. PMCID: PMC4339282.

Nguyen LA, Haws KA, Fitzhugh MC, Torre GA, Hishaw GA, & Alexander GE. (2015) Interactive effects of subjective memory complaints and hypertension on learning and memory performance in the elderly. Aging, Neuropsychology, and Cognition. July 17, 1-17.

Samson, R.D., Venkatesh, A., Lester, A.W., Weinstein, A.T., Lipa, P., & Barnes, C.A. (2015) Age differences in strategy selection and risk preference during risk-based decision making.  Behavioral Neuroscience, 129, 138-148.

Schimanski, L.A. & Barnes, C.A. (2015) Insights into age-related cognitive decline: Coupling neurophysiological and behavioral approaches.  In: H.A. Bimonte-Nelson (Ed) The Maze Book: Your Guidebook to Theories, Practice, and Protocols for Testing Rodent Cognition.  Springer: New York, pp. 121-142.

Corenblum, M.J., Ray, S., Remley, Q.W., Long, M., Harder, B., Zhang, D.D., Barnes, C.A. & Madhavan, L.  (2016) Reduced NrF2 expression mediates the decline in neural stem cell function during a critical middle-age period.  Aging Cell, 4, 725-736.

Gray, D.T., Smith, A.C., Burke, S.N., Gazzaley, A. & Barnes, C.A.  (2016) Attentional updating and monitoring and affective shifting are impacted independently by aging in the macaque monkeys. Behavioral Brain Research.  doi: 10.1016/j.bbr.2016.06.056

Myhre, J. W., Mehl, M. R., & Glisky, E. L. (2016). Cognitive benefits of online social networking in healthy older adults. Journal of Gerontology: Psychological Sciences. doi:10.1093/geronb/gbw025.

Neysari, M., Bodenmann, G., Mehl, M., Bernecker, K., Nussbeck, F. W., Backes, S., Zemp, M. Martin M., Horn, & A. B.(in press). Monitoring pronouns in conflicts: Temporal dynamics of verbal communication in couples across the lifespan. GeroPsych: The Journal of Gerontopsychology and Geriatric Psychiatry.

Penner, M.R., Parrish, R.R., Hoang, L.T., Roth, T.L., Lubin, F.D , & Barnes, C.A. (2016) Age-related changes in Egr1 transcription and DNA methylation within the hippocampus.  Hippocampus, 26, 1008-1020.

Siniard, A.L., Corneveaux, J.J., DeBoth, M., Chawla, M.K., Barnes, C.A. & Huentelman, M.J. (2015) RNA sequencing from laser capture microdissected brain tissue to study normal aging and Alzheimer’s disease.   In: Applied Neurogenomics.  Springer: New York, pp 111-120.

Thome, A., Gray, D.T., Erickson, C.A., Lipa P. & Barnes, C.A. (2016) Memory impairment in aged primates is associated with region-specific network dysfunction.  Molecular Psychiatry.  doi:10.1038/mp.2015.160.

Wiegand, J.-P., Gray, D.T., Schimanski, L.A., Lipa, P., Barnes, C.A., & Cowen, S.L.  (2016) Age is associated with reduced sharp-wave ripple frequency and altered patters of neuronal variability.  The Journal of Neuroscience, 36, 5650-5660.

Alexander, G.E. (In Press). Linking b-amyloid to myelin – An emerging role for imaging white matter in the preclinical risk for Alzheimer’s disease. JAMA Neurology

Neysari, M., Bodenmann, G., Mehl, M., Bernecker, K., Nussbeck, F. W., Backes, S., Zemp, M. Martin M., Horn, & A. B.(in press). Monitoring pronouns in conflicts: Temporal dynamics of verbal communication in couples across the lifespan. GeroPsych: The Journal of Gerontopsychology and Geriatric Psychiatry.